Diphtheria manifests as either an upper respiratory tract or cutaneous infection and is caused by the aerobic grampositive bacteria, corynebacterium diphtheria. Some are saprophytic some produce disease in animals. Corynebacterium diphtheriae health sciences wellness. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Corynebacterium diphtheriae is an aerobic grampositive bacterium which secretes a toxin that inactivates human elongation factor eef2, thus inhibiting translation during protein synthesis by human cells. Most strains require nicotinic and pantothenic acids for growth. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Corynebacteria are pleomorphic rods that occur in angular arrangements.
Hosted by the usgs core science analytics and synthesis. Corynebacterium diphtheriae diphtheria infectious disease and. However, if there are large numbers of pathogenic organisms within the inspired air or if the host defenses are. Diphtheria was a serious contagious disease throughout much of the world until. The bacterium that causes diphtheria was first described by klebs in 1883, and was cultivated by loeffler in 1884, who applied kochs postulates and properly identified corynebacterium diphtheriae as the agent of the disease. Twentyfive cases of nontoxigenic corynebacterium diphtheriae infection were recorded in poland during 20042012, of which 18 were invasive. All strains produce the identical toxin and are capable of colonizing the throat. Corynebacterium diphtheriae is classified into biotypes mitis, intermedius, and gravis. Global population of corynebacterium diphtheriae is mainly represented by local genotypes whose circulation is under strong influence of human host factors, including health control measures, first of all, vaccination, and social economic conditions. While every effort has been made to provide the most reliable and uptodate information available, ultimate legal requirements with respect to species are contained in. In the past, it was mainly through such healthy carriers that the disease was spread, and toxigenic bacteria were maintained in the population.
Corynebacterium diphtheriae study guide by knpearso includes 12 questions covering vocabulary, terms and more. C diphtheria is responsible for both endemic and epidemic diseases, and it was first described in the 5th century bc by hippocrates. Diphtheria is an acute infectious disease that is caused by toxinproducing strains of corynebacterium diphtheriae, a grampositve rod 1. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Diphtheria toxoid 3 doses 2,4,6 years booster dose after every 10 years. Diphtheria is a serious bacterial infection that affects the mucous membranes of the throat and nose. Corynebacterium diphtheriae is a rodshaped, gram positive, non sporeforming, and nonmotile bacterium. Antitoxin neutralizes the unbound toxin in the blood. Corynebacterium diphtheriae is the bacterium that causes the disease diphtheria. Introduction corynebacteria coryneform bacteria a group of nonspore forming, gram positive bacilli, tend to be clubbed or irregularly shaped. Septic osteomyelitis of the hip in a previously healthy child is described.
A weakly toxigeniccorynebacterium diphtheriae strain was isolated from the bone aspirate. Displaying powerpoint presentation on corynebacterium types of bacteria corynebacterium diphtheriae corynebacterium ulcerans corynebacterium available to view or download. The presentation is indolent and nonprogressive and is only rarely associated with signs of. Corynebacterium diphtheriae is spread by droplets, secretions, or direct contact. The toxin produced at the site of the membrane is absorbed into the bloodstream and then distributed to the.
Often, whole families died of the disease in a few weeks. Local manifestation depend on the site of faucial lesion. Pronunciation of corynebacterium diphtheriae with 2 audio pronunciations, 3 synonyms, 2 meanings, 2 translations and more for corynebacterium diphtheriae. It is a gram positive, nonmotile, non spore forming bacteria. Corynebacterium diphtheriae medical microbiology ncbi bookshelf. In this article we will discuss about corynebacterium diphtheriae which causes a disease called diptheria in humans.
The disease occurs primarily in tropical regions and underdeveloped countries but has been known to appear throughout the world. Diphtheria causes a thick covering in the back of the throat. Other articles where corynebacterium diphtheriae is discussed. Although diphtheria disease is rare in the united states, it appears that corynebacterium diphtheriae continues to circulate in areas of the country with previously endemic diphtheria. It is upper respiratory tract illness and it is a contageous disease. Two other zoonotic corynebacterial species, corynebacterium ulcerans and corynebacterium pseudotuberculosis, can also produce diphtheria toxin. Taxonomy navigation corynebacterium all lower taxonomy nodes 25 common name isynonym iother names i bacillus diphtheriae kruse in flugge 1886 bacterium diphtheriae kruse 1886 migula 1900 microsporon diphthericum sic klebs 1875 microsporon. The name of the disease is derived from the greek diphthera, meaning leather hide. Ppt corynebacterium spp and related organisms powerpoint. Formam grandes colonias quando cultivadas em meio agar sangue durante uma noite. Diphtheria communicable disease management protocol diphtheria august 2016 1 this protocol applies to the management of toxinproducing strains of corynebacterium diphtheriae, ulcerans or pseudotuberculosis only. They are listed here by falling order of the severity of the disease that they produce in humans. Corynebacterium diphtheriae respiratory tract infections although inhaled air contains many particles, including microorganisms, the host defense mechanisms in the respiratory tract frequently prevent infection.
Corynebacterium diphtheriae on columbia agar with 5% defibrinated sheep blood. However, it is not a legal authority for statutory or regulatory purposes. Novel nontoxigenic corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Discover everything scribd has to offer, including books and audiobooks from major publishers. Toxigenic strains are lysogenic for one of a family of corynebacteriophages that carry the structural gene for diphtheria toxin, tox. The disease was described in the 5th century bce by hippocrates, and epidemics were described in the 6th century ad by aetius. Corynebacterium diphtheriae the causative agent of diphtheria, which produces a potent exotoxin reservoir humans epidemiology airborne, infected fomites, infected skin. Some corynebacteria are part of the normal flora of humans, finding a suitable niche in virtually every anatomic site, especially the skin and nares. The results of the treatment were rapidly satisfactory, after surgical drainage and antibiotic therapy with pristinamycin. Before mass immunization of children, carrier rates of c. Emad abdelhameed morad lecturer of medical microbiology and immunology. Corynebacterium diphtheriae nkyomniventures xpowerpoint.
Corynebacterium diphtheriae an overview sciencedirect topics. Rapid detection and molecular differentiation of toxigenic. Diphtheria was a serious contagious disease throughout much of. The site of infection, generally the throat, becomes sore and swollen. It is upper respiratory tract illness and it is a contageous disease 1. The toxin inhibits cellular protein synthesis and is responsible for local tissue destruction and pseudomembrane formation 14.
Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Ppt corynebacterium diphtheriae powerpoint presentation free to download id. Corynebacterium diphtheriae disease general microscience. Corynebacterium diphtheriae is a pathogenic bacterium that causes diphtheria. Corynebacterium diphtheriae is a nonmotile, noncapsulated, clubshaped, grampositive bacillus. Corynebacterium diphtheriae is a causative agent of diphtheria. Corynebacterium classification corynebacterium diphtheria and diphtheroids look like c.
Page designed through the cooperative efforts of interagency itis teams. Three strains of corynebacterium diphtheriae are recognized, gravis, intermedius and mitis. However, for 17% of cases, no concomitant diseases or predisposing factors were found. Immunology and vaccinepreventable diseases pink book. Suitable for investigation throat swabs with removal under the false membranes, and nose or wound swabs, tissue if necessary. Diphtheria 107 7 diphtheria is an acute, toxinmediated disease caused by the bacterium. Characterization of corynebacterium species in macaques external icon. Download corynebacterium types of bacteria corynebacterium diphtheriae corynebacterium ulcerans corynebacterium ppt for free. Diphtheria is caused by both toxigenic corynebacterium diphtheriae and corynebacterium ulcerans strains harboring lysogenic betacorynephages bearing the tox x encodes the diphtheria toxin dt, which is responsible for the systemic symptoms of diphtheria. Corynebacteria are grampositive, catalase positive, nonsporeforming, nonmotile, rodshaped bacteria that are straight or slightly curved, with clubbed ends from the greek koryne, club. Novel diphtheriae in domestic cats centers for disease.
Corynebacterium diphtheria produce very potent toxin when infected with a. Diphtheria is an infection caused by the bacterium corynebacterium diphtheriae. Multilocus sequence typing identifies evidence for recombination and two distinct lineages of corynebacterium diphtheriae external icon. Toxigenic strains in susceptible individuals can cause disease by multiplying and secreting diphtheria toxin into either skin or nasopharyngeal. Biotype mitis and gravis produce larger, convex colonies with weak betahemolysis. Corynebacterium introduction the genus corynebacterium consists of a diverse group of bacteria including. The characteristic clinical presentation is the presence of a grayishwhite, fibrinous and firmly adherent pseudomembrane figure 2 that forms within the first few. Alcoholism, homelessness, hepatic cirrhosis, and dental caries were predisposing factors for infection. Quizlet flashcards, activities and games help you improve your grades. Corynebacterium diphtheriae an overview sciencedirect. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
Corynebacterium diphtheriae diphtheria infectious disease. Ppt corynebacterium diphtheriae powerpoint presentation. Corynebacterium diphtheriae wikipedia, a enciclopedia livre. More than half of these are connected to human and animal infections, with the most prominent member of the pathogenic species being corynebacterium diphtheriae, which is also the type species of the genus. Corynebacterium diphtheriae medical microbiology ncbi. Corynebacterium diphtheriae definition of corynebacterium. The bacilli are swollen at one end club shaped bacilli. Corynebacterium diphtheriae is the leading causing agent of diphtheria.
If there is clinical suspicion of diphtheria microbiological laboratory must be informed immediately in order to use in the cultural approach appropriate media. View corynebacterium ppts online, safely and virusfree. The complete genome sequence and analysis of corynebacterium. They are bacilli rodshaped, and in some phases of life they are, more particularly, clubshaped, which inspired the genus name coryneform means clubshaped. The bacterium that causes diphtheria was first described by klebs in 1883, and was cultivated by loeffler in 1884, who applied kochs postulates and properly identified corynebacterium diphtheriae as. Corynebacterium diphtheriae colonies on blood agar. It is a nonmotile, nonencapsulated, nonsporulating grampositive rodshaped bacterium with a high gccontent and occurs in four biovars.
To date the genus corynebacterium comprises 88 species. Nontoxigenic highly pathogenic clone of corynebacterium. Gram positive bacilli arranged in acute angled pairs chineese letter arrangement. After infection by direct contact, sneezing or coughing. Diphtheria is caused by toxinproducing strains of the bacterium corynebacterium diphtheriae 6. Crystal structure of nucleotidefree diphtheria toxin. If so, share your ppt presentation slides online with. Corynebacterium diphtheriae is classified into biotypes mitis, intermedius, and gravis according to colony morphology, as well as into lysotypes based upon corynebacteriophage sensitivity. Although it spreads easily from one person to another, diphtheria can be prevented through the. Contact investigation and carrier study of human and animal contacts.
Morphology gram positive bacilli arranged in acute angled pairs chineese letter arrangement. Remove this presentation flag as inappropriate i dont like this i like this remember as a favorite. Itis taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties. In situ lysogenic conversion of nontoxigenic strains to a toxigenic phenotype.
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